Scientists can create fruit flies that live a 250% longer life span. We are also finding many ways to get old human cells to behave like young ones do. “Unless ye be as little children, you cannot enter the Kingdom of Heaven,” so lets get started on our second childhood, right away. You’ll not only have more fun in your function, you’ll likely enjoy living longer as well…
Attitude: Gratitude. Don’t worry, be happy. A study of 1,500 centenarians found that diets, activity levels, and smoking habits varied widely, but nearly all have a good sense of humor and don’t worry.
Calorie restriction is crucial. The best way to restrict calories is to focus your diet on greens and vegetables and minimize commercial, refined and processed foods, sugars and carbohydrates. Make sure you get an adequate balance of protein, but not an excess. The common American diet contains 4 times the optimal protein. Reduce calories to about two-thirds of what it takes to maintain your normal weight if you are at all overweight. Initial weight loss tapers off as your metabolism adjusts to a lower metabolic rate. Get plenty of antioxidants in your diet to prevent free-radical damage. Occasionally enjoy no sulfite added wines if tolerated and eat lots of berries. See below for specific antioxidant nutrients.
Keep homocysteine low. High levels of homocysteine correlate strongly with most degenerative diseases of aging, especially heart attacks and strokes. You can check your homocysteine level with a blood test if you want. You can lower homocysteine by eating raw fresh organic dark leafy greens and taking methyl donors, the most commonly deficient vitamin group on commercial food diets.
Avoid sugar and minimize grains.
Resveratrol from grapes (Vitis vinifera) or giant knotweed (Polygonum cuspidatum) extends the life of yeast (Saccharomyces cerevisiae) cells by 70% via a niacin-dependent enzyme, Sir2. Humans have a homologous enzyme SIRT1, a deacetylase. Resveratrol works synergistically with Quercetin (water soluble Quercetin is best absorbed). Resveratrol is found in wine, with white wine containing only about 10% of red’s 200 to 5,000 mcg per glass.
Polygonum multiflorum (Fo ti, Ho Shou Wu, Japanese knotweed) and Centella asiatica (gotu kola) are thought to extend longevity. Polygonum multiflorum is said to contain Vitamin X. Pharmacology studies show that an extract improves the cardiovascular system, enhances immune functions, slows degeneration of glands, increases antioxidant activity, and reduces the accumulation of lipid peroxidation.
Chen Keji and Zhang Wenpeng, Advances on antiaging herbal medicines in China , Abstracts of Chinese Medicine 1987; 1(2): 309-330.
Processed Polygonum multiflorum affects the antioxidant enzyme superoxide dismutase (SOD), accumulation of lipid peroxidase, and enhances cellular immunity, while unprocessed herb is much less effective.
Ye Dingjiang, et al., Immunopharmacological studies of ho-shou-wu and its preparations , 1987 Bulletin of Chinese Materia Medica 12(3): 21-24.
Pan Hongping, Wang Hong, and He Tingcai, Processed root tuber of Polygonum multiflorum on SOD and LPO levels in mice , China Journal of Chinese Materia Medica 1993; 18(6): 344.
Among the Chinese herbal prescriptions tested and shown useful for lowering the risk factors associated with aging and death, were (15):
Shou Xing Bu Zhi: with main components ho-shou-wu, dioscorea, rehmannia, codonopsis (or ginseng)
Essence Restoring Decoction: with main components ho-shou-wu, rehmannia, cuscuta, astragalus, achyranthes, and cynomorium.
Rejuvenating Decoction: with main ingredients ho-shou-wu, astragalus, and salvia.
Other antiaging botanicals studied extensively include:
Panax quinquifolia (ginseng)
(dong quai, tang-kuei)
Eleutherococcus senticosus (Siberian ginseng, eleuthero ginseng)
Avoid conventional medicine: Mortality rates are 2 to 5% higher in regions that spend more on conventional medicine, comparing areas with the same level of health. Every time physicians and surgeons go on strike, the death rate drops, until they go back to work. This has been documented in Israel, California, South America and elsewhere.
Gerovital: GH3: Ana Aslan’s clinic in Romania has treated tens of thousands of people by injection. Drug-free GH3 is now available in oral form.
Live Fetal Lamb Cells: over 50,000 patients have been treated at Clinic La Prairie in Switzerland with fresh fetal lamb cell injections.
M-state minerals: Human blood typically lives only about 10 minutes out of the body, but in rare cases stays alive for hours or even days. One alchemist and his partner found their blood stayed alive for three days after years of ingesting m-state minerals. This effect is only found in one out of thousands of samples, usually in those with strong spirituality.
Vitamin C: supplementation of at least 750 to 1,000 mg twice a day is recommended. Consider fat soluble vitamin C (Ascorbyl Palmitate) which is a form of the antioxidant that gets into the cell membranes that are highly sensitive to oxidation, and Ester C, which gets into the cytoplasm twice as well as ascorbic acid and stays in the cells twice as long.
CoQ10: protects against heart disease. Having a high CoQ10 level and a low homocysteine level keeps you out of the Emergency Room. Consider taking 100 mg of CoQ10 daily if you are in Phase 1 or have a high heart risk. Blood levels can be monitored if necessary.
L-Carnosine: Physiological concentrations (20-30 micromoles) in standard media prolong the in-vitro life span of human fibroblast cells and strongly reduce the normal features of senescence (aging). In laboratory studies, carnosine clearly improves external appearance of animals and produces beneficial effects on behavior and average life span. Benefits include:
most effective natural glycation fighter
protects proteins from AGE toxicity
extends lifespan 20 % in senescence-accelerated mice
dramatically improves behavior and appearance of old mice
rejuvenates senescent human cells in culture
increases cell life span
restores youthful appearance and growth patterns to cells approaching senescence
Alpha Lipoic Acid & Acetyl L-Carnitine:
Age-Related Mitochondrial Decay Increases Oxidative Stress in the Aging Rat Heart: Improvement by Acetylcarnitine and/or (R)-A-Lipoic Acid
T.M. Hagen and R. Moreau
Department of Biochemistry and Biophysics and the Linus Pauling Institute, Oregon State University
Mitochondria are critical to cell function. They are the site of energy production for the cell and play a critical role in cellular calcium balance. They also serve as a “gatekeeper” for apoptosis (self-induced cell death). Mitochondria are both the source and the target of reactive oxygen species, which induce oxidative damage leading to energy deficits, metabolic upset, and ultimately cell death.
We compared mitochondrial function in isolated heart, liver and brain cells of young and old rats. Energy production and electron transport efficiency was decreased in the cells from the old animals. Cardiolipin, a substance needed for proper mitochondrial function, was reduced by 52% in the old rats. A similar decrease occurred in ubiquinone, an important component of mitochondrial energy production. The older rats also had decreased concentrations of carnitine, a substance that transports fatty acids into the mitochondria for energy production.
We evaluated the antioxidant status of the liver and heart cells. Total cell glutathione level in the old rats was reduced by about 40% compared to the levels in younger rats. Mitochondrial glutathione was reduced by 79% in the old rats, possibly due to additional oxidative stress with age. The ascorbate (vitamin C) content of both the heart and liver cells from the old rats was reduced by half in the older rats. This may indicate an increased rate of ascorbate utilization or a decreased rate of uptake. Iron content was significantly increased in the brain cells from the old rats. These age-related changes in antioxidant status and iron content create a favorable environment for production of dangerous free radicals.
Acetylcarnitine is a naturally-occurring compound used to shuttle fatty acids to the mitochondria, where they are converted to energy. It may also increase neurotransmitter levels, such as acetylcholine.
To test whether acetylcarnitine supplementation improved mitochondrial function in old rats, we fed an acetylcarnitine-supplemented diet to young and old rats. Acetylcarnitine caused certain mitochondrial membrane properties in the old animals to improve to the level observed in young animals. Supplementation also increased or restored the cardiolipin content in liver cells obtained from old rats, but did not restore cell ascorbate content.
Lipoic acid is another naturally-occurring antioxidant compound that stimulates production of glutathione. It is considered to be a better antioxidant capabilities than even ascorbate.
To test the effect of lipoic acid on aging, we fed a lipoic acid-supplemented diet to young and old rats for two weeks. In the old animals, supplementation reversed the age-related decrease in ascorbate content in heart and liver cells. It also improved the ascorbate content in the cells from the young animals. Lipoic acid supplementation also reversed the accumulation of iron in the brain cells of the old animals.
In conclusion, we found that aging impaired mitochondrial and cellular function of liver, heart and brain cells. The results of our dietary studies indicate that supplementation with acetylcarnitine and lipoic acid may retard or reverse this impairment.
This research was supported by the National Institute of Aging.
2-AEP is a component of the outer cell membrane.
Many hormone levels decline with aging. In some instances hormone replacement therapy may be quite beneficial, especially when combined with individual detoxification, nutrition and regeneration support. Some of the important anti-aging hormones are:
7-Keto repletes hypoadrenal states without directly increasing sex hormone levels.
DHEA is the precursor of many hormones, including progesterone.
Estrogen replacement therapy is not generally recommended by most holistic practitioners. When needed, natural forms such as Triest are most biocompatible. Phytoestrogens are often a better choice for therapy.
HGH: In 1990, Dr. Daniel Rudman published his human growth hormone research studies on the effects of longevity and life extension with Hgh in the New England Journal of Medicine. Six months of HGH injections reversed the aging process between 10 and 20 years. Now HGH is available in oral homeopathic forms. Growth hormone can directly reverse some aging effects, improve muscle strength and mass, reduce wrinkles and sagging skin, and decrease joint pain and inflammation. Consider supplementing HGH, or boosting levels with releasers.
Pregnenolone is the precursor of DHEA.
Progesterone is often used as a cream, but is also available as oral drops in a base of Vitamin E for better absorption.
Physical activity can prevent or delay the onset of hypertension, obesity, heart disease, falls, and osteoporosis. Rebound exercise is the most efficient and gentle exercise for every cell in the body.